Yashoda Hospitals > Medicine FAQS > Jardiance

Jardiance: Frequently Asked Questions Answered

Introduction

Jardiance is an anti-diabetic drug used in adults to treat type 2 diabetes. In 2014, the FDA approved this drug. It is used alone or in combination with other anti-diabetic drugs. The FDA accepted Jardiance for decreasing diabetic-associated mortality, especially cardiovascular events associated with type 2 diabetes mellitus. 

The drug works by inhibiting sodium-glucose co-transporter-2 found in the proximal part of the kidney. Hence, the drug decreases renal absorption and increases the renal excretion of glucose.

What are the uses of Jardiance?

Jardiance is useful for treating type 2 diabetes mellitus in adult patients. Its glucose-lowering effect through renal excretion is associated with its diuretic properties. The medication reduces sodium levels and volume overload, causing a reduction in blood pressure without increasing the heart rate. 

Jardiance is helpful for patients with cardiovascular diseases (CVDs) and type 2 diabetes mellitus and patients with a history of diabetes associated with nephropathy. It is used as a third-line agent along with metformin & insulin as well as a second-line agent along with metformin in patients who cannot tolerate insulin and have a history of weight gain and hypoglycemia.

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    What are the side effects of Jardiance?

    • Jardiance has several side effects including hypotension, genital fungal infections and hypoglycemia when used in combination with insulin. 
    • Rarely it is associated with serious side effects such as the acute necrosis of the scrotum, penis or the perineum (Fournier Gangrene) and pyelonephritis. 
    • If you have renal problems, you should take precautions as directed by the doctor. The drug cannot be prescribed if your glomerular filtration rate is less than 45 mL/min. 

    What is Jardiance

    Uses of Jardiance

    Side effects of Jardiance

    References

    Disclaimer: The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.

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    Frequently Asked Questions about Jardiance

    Jardiance can lower blood sugar levels within 1-2 weeks, but the drug should be taken under proper monitoring for at least 24 weeks to obtain full therapeutic effects. A sudden hypoglycemic effect is less commonly seen in people taking Jardiance unless used in combination with insulin.

    Jardiance should be taken in the morning for maximum benefits. According to studies, an initial morning dose of 10 mg is recommended, and the dosing can be increased to 25 mg if you are able to tolerate the initial dosing.

    Yeast infections on the genital area in patients taking Jardiance are more common. It is essential to take precautions such as keeping the genital area dry, using loose cotton fabrics and maintaining good personal hygiene. In case of repeated infections, it is advisable to consult with a doctor.

    Fournier Gangrene, the gangrene associated with the perineum (area between the genitals and the rectum ) or the scrotum, is the dangerous side effect of Jardiance. It is a rare and life-threatening bacterial infection. Therefore, you should consult your doctor immediately if you notice any symptoms.

    Yes, Jardiance can be given as a third-line drug along with metformin and insulin and a second-line drug along with metformin. However, there is a higher chance of hypoglycemia if it is given along with insulin and metformin.

    Yes, Jardiance will make you thirsty. Increased thirst and signs of dehydration such as decreased urine output, dry skin, sticky mouth and dizziness are unusual side effects of Jardiance. Therefore, it is advisable to drink water frequently while on this medication.

    Although there is a direct correlation between Jardiance and weight loss, researchers are yet to prove any relationship between appetite-producing hormones and the drug. A phase IV clinical trial had shown a correlation between appetite-producing hormones and Jardiance. However, further large scale studies are necessary to establish this correlation.

    Jardiance prevents heart failure and reduces the risk of cardiovascular events in patients having type II diabetes mellitus. Its effectiveness in patients having atherosclerotic CVD and suboptimal glycemic levels also depends on lifestyle modifications. Several studies showed that Jardiance has greater cardioprotective effects and reduced mortality rates compared with those in the placebo group. This cardioprotective effect is because of the increased diuretic activity of the drug.

    Presently, there is no evidence to support this statement. Although Jardiance has a cardioprotective effect because of its diuretic action, which reduces sodium and volume overload, the drug does not prevent coagulation. Hence, the medication does not act as a blood thinner. Moreover, no drug interactions are found between Jardiance and other anticoagulants.

    Liraglutide, a GLP -1 receptor agonist, has a similar action like Jardiance. Canagliflozin is also another option. Jardiance is a costly drug, and the generic version of the drug is not available. Moreover, considering its severe side effects, you should consult with your doctor if you need an alternative to the medication.

     

    CTA: Consult our doctors at Yashoda Hospital for an expert opinion to clear all your doubts.