Yashoda Hospitals > Medicine FAQS > Dapagliflozin

Dapagliflozin: Frequently Asked Questions Answered

What is Dapagliflozin?

Dapagliflozin is the first-class FDA-approved SGLT2 inhibitor (sodium-glucose co-transporter 2 inhibitors) that took a fresh approach to glycemic control in adults with type 2 diabetes. It works by helping the kidneys get rid of glucose through urine to lower your blood sugar level. When combined with diet and exercise, it controls high blood sugar.

What are the uses of Dapagliflozin?

Under the supervision of a professional, Dapagliflozin is approved for use in adult patients with Type 2 diabetes. Dapagliflozin may also be recommended if you are overweight or large doses of insulin are not adequately managing your blood sugar, but only under the supervision of a professionally qualified physician.

Dapagliflozin uses are as follows:

  1. Helps adults with type 2 DM.
  2. Reduces the risk of heart disease mortality.
  3. Reduces the risk of diabetic coma (in DM Type II).
  4. Reduces the risk of diabetic ketoacidosis (in DM Type II).
  5. Reduces the risk of heart failure with reduced ejection fraction.

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    What are the side effects of Dapagliflozin?

    Dapagliflozin, like other medications, can have side effects, but not everyone experiences them. As your body becomes used to the medication, the side effects usually improve. These frequent side effects happen in 1 out of 100 patients, classified as mild or serious;

    MILD SIDE-EFFECTS

    • Bladder infection — pain or burning while urination, increased urination, blood in urine, fever, pain in the pelvis, or back.
    • Lactic acidosis — muscle discomfort, difficulty breathing, stomach pain, vomiting, abnormal heart rate, disorientation, feeling chilly, or feeling extremely weak.
    • Respiratory infection — common cold or flu.

    SERIOUS SIDE-EFFECTS

    • Genital infections (vulvovaginitis and balanitis).
    • Hypoglycemia.
    • Dehydration.
    • Urinary tract infection.
    • Kidney damage like diabetic ketoacidosis (DKA).
    • Fournier’s gangrene (severe infection near the genitals).

    This is not an exhaustive list of possible side effects; more may arise. To avoid side effects, pay close attention to dosages and precautions. If you notice any of these symptoms, please contact our medical professionals at Yashoda Hospitals.

    What is Dapagliflozin

    Uses of Dapagliflozin

    Side effects of Dapagliflozin

    References

    1. https://academic.oup.com/jcem/article/97/3/1020/2536455
    2. https://www.nhs.uk/medicines/Dapagliflozin/
    3. https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.119.044138
    4. https://www.diabetes.co.uk/diabetes-medication/forxiga-Dapagliflozin.html

    Disclaimer: The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.

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    Frequently Asked Questions about Dapagliflozin

    Unlike certain diabetic medications, Dapagliflozin does not cause weight gain. Many patients report losing weight instead. This occurs through a fluid loss mechanism during the first phase of therapy, followed by a more steady reduction through a net calorie deficit (usually 200–300 kcal/day).

    Dapagliflozin is an SGLT2 inhibitor that acts in the proximal nephron and is responsible for releasing filtered glucose into circulation. This operates by causing your kidneys to extract more sugar from your blood and excreting it through your urine. Inhibiting this cotransporter lowers glucose recovery, increases glucose excretion, and lowers hyperglycemia.

    Both Empaglifozin and Dapagliflozin are given to people with TYPE2 DM, usually in combination with a healthier diet and exercise. The key difference between them is based on improving other cardiometabolic markers. Empagliflozin is considered more effective than Dapagliflozin in lowering HbA1c and also lowers the risk of mortality from heart failure and stroke.

    Metformin is still the safest, most effective type 2 diabetes medication. Both are mainly used as combination medication to enhance blood sugar management. Dapagliflozin acts in the kidneys to prevent blood sugar absorption, while Metformin lowers the absorption of sugar from the stomach and liver, thus improving the body's glucose utilisation.

    Renal dysfunction is one of the most prevalent complications of uncontrolled type 2 DM, especially when proteinuria and obesity are present. Dapagliflozin affects the kidneys by increasing the quantity of sugar eliminated via the urine. In type 2 diabetes patients, SGLT2 inhibitors minimise renal glucose reabsorption and enhance glycemic control.

    Dapagliflozin causes a modest rise in serum creatinine levels in the blood generated by skeletal muscle. This response is triggered mainly by the patient's age, renal illness, history of asthma medications, high BP, and heart disease that affects the urine glucose excretion. If this level rises by >40%, it might be an indication of diabetic complications.

    Dapagliflozin is generally safe to use. Make sure your doctor has approved its usage and is aware of other medicines you are taking. For those who already have diabetes, this medication may induce severe low blood sugar episodes.

    According to the outcome of research published in the Journal of the American Heart Association, Dapagliflozin dramatically improves both systolic and diastolic heart failure symptoms as well as ejection fraction. Dapagliflozin inhibits glucose reuptake in the kidneys, lowers blood sugar levels, and alleviates diabetes symptoms.

    Dapagliflozin is a selective SGLT2 inhibitor that inhibits glucose resorption in the kidney's proximal tubule, increasing urine glucose excretion and lowering blood glucose levels. It makes it simpler for the body to pass through urine by reducing the quantity of sugar produced by the liver as well as sugar absorption in the gut.

    Dapagliflozin is not suitable for all diabetic patients. Tell your doctor before starting the medicine in the following instances:

    • Low kidney functions.
    • Liver disease.
    • History of allergic reaction to DM meds before.
    • Have > glucose and ketones levels in urine.
    • Heart disease.
    • Type I DM.
    • Have recurrent UTIs.
    • Pregnant or breastfeeding mothers.
    • Galactose intolerance.
    • Have low salt levels in their body.
    • Are < 18 yrs or > 75 yrs.
    • People on loop diuretics.
    S.no Product Name Dosage Form
    1. Oxra Dapagliflozin 5mg Tablet
    2. Dapadel Dapagliflozin 10mg Tablet
    3. Delpizin Dapagliflozin 5mg/10mg Tablet
    4. Zucapride Dapagliflozin 5mg Tablet
    5. Dajio Dapagliflozin 5mg Tablet