Yashoda Hospitals > Diagnostics > Thyroglobulin test

What is the Thyroglobulin test?

The thyroid is a small, butterfly-shaped gland at the back of our throats, and it secretes a protein called thyroglobulin. While most of the thyroglobulin produced stays in the thyroid itself, a minute amount often seeps into the bloodstream. The thyroglobulin test results are high for people who have been detected with thyroid cancer. 

The thyroglobulin test is usually prescribed after thyroid cancer surgery, as a check to see if the cancer has returned or not. The test is not used for the detection of thyroid cancer, as healthy cells also contain thyroglobulin. Rather, it checks to see the status of existing thyroid cancer cells in patients. 

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    References

      https://www.uhn.ca/PatientsFamilies/Health_Information/Health_Topics/Documents/Understand_Blood_Test_Results-differentiated_thyroid_cancer.pdf
      https://www.hindawi.com/journals/dm/2015/648670/
      https://www.portea.com/labs/diagnostic-tests/thyroglobulin-test-188/
      https://labs.selfdecode.com/blog/thyroglobulin/
      https://medlineplus.gov/lab-tests/thyroglobulin/#:~:text=What%20is%20a%20thyroglobulin%20test,help%20guide%20thyroid%20cancer%20treatment.

    Frequently Asked Questions

    Doctors use the thyroglobulin test as a check of carcinogenic cells post-treatment, for thyroid cancer. After one year of surgery, if the thyroglobulin levels continue to rise, it is an indication that the cancer has returned. If levels remain undetectable, the risk of return is low. The thyroglobulin test is used as a measure to monitor the status of the already detected thyroid cancer, and not as a primary detection tool.

    • If the test results of the thyroglobulin levels are high or have increased, this is an indication of the growth or spread of the thyroid cancer cells.
    • If the thyroglobulin levels decreased initially, but then increased over time, it is an indication of the return of cancer, despite successful treatment.
    • If the thyroglobulin levels are minute, this indicates successful and complete treatment of cancer cells. 

    If you have been treated for thyroid cancer, your doctor will prescribe a thyroglobulin test to keep a check on the cancer cells. Shortly after the treatment, you will be tested regularly, with the frequency of tests reducing as time progresses. Once the thyroid has been removed, the bloodstream needs to be checked for residual levels of thyroglobulin. 

    A thyroglobulin test is like a simple blood test. During the test, the doctor or health care provider will insert a needle and draw a small vial of blood that will be sent to the laboratory for testing. Quite painless, there are no side effects to the test. The entire process should not take more than 5 minutes.

    The normal thyroglobulin range in healthy people without the thyroglobulin antibody (TgAb) ranges from 3-40 ng/mL. Women tend to have slightly higher thyroglobulin levels as compared to men. The range of acceptable thyroglobulin levels might be higher in countries where there is an iodine deficiency.

    Some common symptoms indicative of high thyroglobulin levels are:

     

    • Unexplained weight gain/loss
    • Constipation 
    • Dry and coarse skin
    • Fatigue and unexplained tiredness
    • Insomnia
    • Goitre

    3-40 ng/mL is considered to be the normal thyroglobulin levels in a healthy person. Any reading of more than 40 ng/mL is considered to be a high level of thyroglobulin in the bloodstream. This is indicative that the cancer cells have started to grow and/or are spreading in the body. Measures must be taken immediately to control the same.

    A positive thyroglobulin test is indicative of growing and spreading cancer cells. Post the thyroid surgery, there should be no thyroglobulin present in the bloodstream. If the thyroglobulin test shows the presence of the protein, the cancer is growing. An ultrasound of the neck area will help to confirm the same.

    No, the thyroglobulin test does not require fasting. There are no preparations that the patient must make in advance. However, it is advised to not consume any multivitamins and biotin (vitamin B7) for 12 hours before giving the test as it could interfere with the results. There are no side effects to the thyroglobulin test either.

     

    The size of the thyroid gland affects the levels of thyroglobulin found in the bloodstream. High thyroglobulin levels are caused due to the presence of disorders like cancer, nodules, or autoimmune diseases that reduce the size of the thyroid.

    Book your appointment now for a thyroglobulin test and to Get a free second opinion