Yashoda Hospitals > Diagnostics > Estradiol (E2) Test

What is an estradiol or E2 test?

E2 test Stands for Estradiol Test. It is a blood test used to measure the amount of estradiol (E2) in your blood. Estradiol is a type of estrogen hormone. It plays a vital role in the development of the female reproductive system, including the uterus, fallopian tubes, vagina, and breasts. High levels of E2 were found in women during their reproductive age, and after menopause, the levels of E2 lowers significantly.

Estradiol tests provide valuable information about ovarian function and aid doctors in evaluating menstrual issues, such as abnormal bleeding or missed periods. The test can also be used to assess the health of the testes, ovaries, or adrenal glands.

What is the use of an estradiol test?

Estradiol tests are used to:

  • Investigate reasons for early or late puberty in girls and late puberty in boys.
  • Monitor treatments for menopause.
  • Identify tumors that produce estrogen.
  • Diagnose certain birth defects during pregnancy and monitor high-risk pregnancies.
  • Diagnose menstrual difficulties and causes of infertility.
  • Monitor infertility treatments.

This comprehensive test helps in various reproductive health evaluations and treatments.

Understanding the test results of the estradiol (E2) test.

Test results may vary depending on your age, gender, and the method used for the test.

If your results are lower, it may mean you have ovarian failure, also called early menopause, or polycystic ovarian syndrome (PCOS).

If your results are higher, it may suggest early puberty, a tumor of the ovary or testes, hyperthyroidism, or adrenal glands.

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    Frequently Asked Questions

    An estradiol (E2) test is necessary if you experience difficulties in getting pregnant, menstrual problems, ovarian tumors, early puberty in adolescents, menopausal symptoms, or breast cancer. Additionally, healthcare practitioners use this test during infertility treatment with assisted reproductive technology (ART) to monitor hormone levels throughout the process.

    During the estradiol test, a technician draws blood from a vein, typically inside the elbow area, after cleaning it with alcohol. The blood is collected in a test tube. This process takes only a few minutes. It is important to note that while the estradiol test can indicate abnormal levels, it alone cannot diagnose a specific disease. Further tests may be recommended by your doctor for a more accurate diagnosis if needed..

    Estradiol levels vary with life stages. In females, the normal range for premenopausal women is 30 to 400 pg/mL, while postmenopausal levels are typically 0 to 30 pg/mL. In males, the normal range of estradiol is usually 10 to 50 pg/mL. Monitoring estradiol is crucial for assessing reproductive health and identifying hormonal imbalances, guided by a healthcare professional's expertise.

    Serum estradiol is an important determinant of an IVF's success. The pregnancy rate is better when E2/fol is between 200 and 299.99 pg/ml. Peak estradiol levels during IVF, at the time of HCG trigger, are generally between 1000 and 4000 pg/ml. Consult your fertility specialist for personalized guidance based on your specific IVF treatment plan.

    High estradiol levels may indicate ovarian issues, leading to suppressed FSH levels and ovulation problems. This condition could make it difficult to conceive even after treatment. It's crucial to consult a healthcare professional to address the underlying causes and explore appropriate options for conception.

    High estradiol levels in women can cause acne, loss of sex drive, constipation, and depression. If the levels are extremely high, they can increase the risk of uterine and breast cancer, as well as cardiovascular diseases. In men, high estradiol levels might lead to some female characteristics and sexual dysfunction. Consult a healthcare professional for proper evaluation and management.

    Estradiol levels decrease during menopause. This hormone plays a role in regulating metabolism and body weight. Lower estradiol levels may contribute to weight gain.

    When the levels of estrogen and testosterone in your body are not properly balanced, you might experience several symptoms associated with high estrogen. These symptoms include mood swings, irregular periods, spotting, heavy bleeding, headaches, bloating, swollen or tender breasts, fatigue or sleepiness, trouble sleeping, anxiety, and weight gain. If you notice these symptoms, it's essential to consult a healthcare professional for a proper evaluation and appropriate management to address the underlying hormonal imbalance.