Yashoda Hospitals > Diagnostics > Anti CCP Test

What is an anti-CCP test?

The Anti-CCP test, short for Anti-Cyclic Citrullinated Peptide Antibodies Test, is also known as the citrulline antibody, CCP antibody, or anti-citrulline antibody test. It’s commonly used to measure the levels of specific antibodies called anti-cyclic citrullinated peptide antibodies (ACPAs). These antibodies are found in approximately 60% to 70% of people who have rheumatoid arthritis (RA).

These autoantibodies, which target the body’s cyclic citrullinated peptide, are an example of an immune reaction gone wrong. The development of RA is connected to this immunological response.

Please note that while the information provided is generally accurate, the percentages of people with ACPAs in RA can vary, and it’s essential to consult a healthcare professional for a comprehensive understanding of test results and their implications.

What is an anti-CCP test used for?

The anti-CCP (anti-cyclic citrullinated peptide) test is valuable in the early detection of rheumatoid arthritis (RA) even before clinical symptoms appear. Identifying RA at this stage is crucial for early intervention and preventing extensive joint damage. This test aids in both diagnosing the disease and assessing its severity, helping healthcare professionals provide timely and appropriate care.

Understanding the test results of Anti CCP (ACCP) Test - normal and high values

Citrullination is a normal physiological process that occurs in the body, particularly in dying cells. The levels of citrulline produced can vary based on a person’s genetics. In the Anti-CCP test, the results are measured in EU/ml (enzyme units per milliliter).

Anti-CCP Test Result (EU/ml)

Interpretation

Less than 20

Negative (Normal)

20-39

Weakly Positive

40-59

Moderately Positive

More than 60

Strongly Positive

A positive result in an asymptomatic individual may suggest an increased risk of developing rheumatoid arthritis (RA) in the future. Conversely, a high positive result in a patient with RA may indicate a higher risk of developing a more severe, erosive form of the condition. However, it’s important to note that an ACCP test alone is not a definitive diagnostic tool, and clinical evaluation by a healthcare provider is essential for accurate assessment and diagnosis.

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    Frequently Asked Questions

    The normal range for the Anti-CCP (Cyclic Citrullinated Peptide) test is typically defined as having a result of less than 20 EU/ml (Enzyme Units per milliliter). Results falling within this range are considered negative and are within the normal limits. However, it's important to note that specific reference ranges may vary slightly between different laboratories and healthcare institutions.

    An anti-CCP test is necessary if your physician suspects rheumatoid arthritis (RA) due to symptoms like joint pain, morning stiffness, fatigue, skin nodules (particularly near the elbows), and low-grade fever. It is an important diagnostic and prognostic tool that helps in predicting the severity of the disease and the effectiveness of various treatments. It also helps to differentiate RA from other types of arthritis.

    The anti-CCP test is a simple blood test wherein a blood sample is taken from the patient through a vein. The procedure takes only a few minutes. It is then sent to the laboratory for testing to find the level of ACPAs in the blood.

    Similar to any test that involves drawing a blood sample with a needle, the anti-CCP test carries certain risks, including the possibility of bleeding, infection, bruising, or dizziness. You may also experience some discomfort when the needle is inserted into your arm, and the injection site may remain slightly sore for a while afterward.

    No, there are no prerequisites for the test. You don't need to fast before the test. However, let your physician know about all medicines, herbs, vitamins, and supplements you are taking, including any medications not requiring a prescription or any other substances you might use or abuse. You may need to stop taking certain substances eight hours before the test, as indicated by your physician.

    According to research, the most common anti-CCP2 test has a sensitivity of 61.6-75.2% for rheumatoid arthritis and a specificity of 94-99%. Therefore, this test is considered highly accurate. However, it's important to note that there can be false-positive cases, as this test has a false-positive rate of 12.5%.

    A positive anti-CCP (anti-cyclic citrullinated peptide) test result typically indicates the presence of autoantibodies associated with autoimmune conditions, primarily rheumatoid arthritis (RA). Treatment for anti-CCP test-positive individuals often includes medications such as disease-modifying antirheumatic drugs (DMARDs) and nonsteroidal anti-inflammatory drugs (NSAIDs), along with lifestyle modifications and regular monitoring by a healthcare provider. Early intervention and personalized treatment plans are crucial in managing RA effectively.

    A positive anti-CCP (anti-cyclic citrullinated peptide) test result is primarily associated with rheumatoid arthritis (RA). RA is the disorder most frequently associated with a positive anti-CCP test, while systemic lupus erythematosus (SLE) and psoriatic arthritis are also autoimmune diseases that are less frequently associated with this marker. However, it's important to note that a positive anti-CCP test result is most strongly indicative of RA.