Yashoda Hospitals > Medicine FAQS > Teicoplanin

Teicoplanin: Frequently Asked Questions Answered

What is Teicoplanin?

Teicoplanin belongs to the semisynthetic glycopeptide class of antibiotics. It consists of five major compounds, A2-1 to A2-5, and four minor compounds, RS-1 through RS-5. Besides having a glycopeptide core, teicoplanin A3-1, the side chains attached to D-glucosamine moiety differ in length and conformation. It is used in cases of gram-positive bacterial infections, for prophylactic measures, and in cases of penicillin allergies and methicillin-resistant infections. It is available in the market in various formulations such as tablets, capsules, syrups, creams, gel, injection, ointment, and liquid.

What are the uses of Teicoplanin?

Teicoplanin is a glycopeptide antibiotic used to treat bacterial infections, complicated skin and soft tissues infections, bone and joint infections, community-acquired pneumonia, community-acquired urinary tract infections, infective endocarditis, peritonitis, and severe bacteremia. 

It is effective on hard and soft tissue infections, shows effective antibacterial activity against gram-positive bacteria, and has a spectrum similar to Vancomycin. Teicoplanin is advised in the use of both uncomplicated and complicated bacterial infections.

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    What are the side effects of Teicoplanin?

    Teicoplanin is to be used under medical supervision. Common and significant side effects include: 

    • Pain or swelling in the injection site.
    • Itching, skin rashes.
    • Erythema.
    • Diarrhea.
    • Dizziness.
    • Nausea.
    • Vomiting.
    • Headache.
    • Abscess. 

    Teicoplanin can cause serious side effects such as:

    • Hypersensitivity.
    • Nephrotoxicity.
    • Infusion-related reactions.
    • Severe bullous reactions.
    • Thrombocytopenia.
    • Ototoxicity and superinfections.
    • Seizures.  

    If you experience any side effects, it is recommended to consult your doctor immediately.

    Consult our medical experts available 24*7 at Yashoda Hospitals for more information on Teicoplanin uses, side effects, dosages and precautions.

    What is Teicoplanin

    Uses of Teicoplanin

    Side effects of Teicoplanin

    References

    1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102624/
    2. https://go.drugbank.com/drugs/DB06149
    3. https://academic.oup.com/bja/article/115/4/595/240287
    4. https://pubmed.ncbi.nlm.nih.gov/21543038/#:~:text=Conclusions%3A%20We%20suggest%20that%20there,in%20patients%20with%20renal%20dysfunction.
    5. https://www.sciencedirect.com/science/article/abs/pii/S0021967319308805
    6. https://handbook.ggcmedicines.org.uk/guidelines/infections/teicoplanin-inpatient-dosing-guidelines-age-16-and-over/
    7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952976/
    8. https://www.medicines.org.uk/emc/medicine/27321

    Disclaimer: The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.

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    Frequently Asked Questions about Teicoplanin

    Various factors such as molecular size, lipophilicity, and plasma protein binding affect the ability of the drug to cross the blood-brain barrier. Teicoplanin shows a plasma binding rate of approximately 90% and is hydrophilic with a high molecular mass. Compared to other glycopeptide antibiotics, Teicoplanin shows a lower rate of penetration into the blood-brain barrier.

    Teicoplanin should be stored away from heat and light. Excessive exposure can damage the medicines. You should keep it in a safe place away from the reach of children. In some instances, patients experience photosensitivity when using Teicoplanin. It is advisable to consult your doctors and take added measures to protect yourself from sunlight.

    There is limited data regarding the use of Teicoplanin in pregnant women, but various animal studies suggest toxicity in high doses. Hence, Teicoplanin is not recommended for use during pregnancy and breastfeeding unless necessary. When used during pregnancy, there is a potential risk of the fetus' inner ear and renal damage. Consult with a doctor regarding precautions, complications, and benefits before use.

    Teicoplanin is used to treat bacterial infections caused by gram-positive bacteria. It has a similar mechanism of action, spectrum, and activity to Vancomycin. It is administered in the cases of penicillin allergy as a second-line of treatment. Teicoplanin is helpful in the treatment of certain bacterial infections, such as:
    • Skin.
    • Soft tissues
    • Blood.
    • Heart.
    • Lungs.

    Teicoplanin is a glycopeptide antibiotic. The medication helps kill bacteria by inhibiting the formation of protective bacterial cell walls needed for their survival. It is poorly absorbed when administered orally and around 90% bioavailable when administered intramuscularly. It can also be administered intravenously and applied topically in cases of infections and for prophylactic purposes.

    The dosage and administration of Teicoplanin depend on the type and severity of the infection. Teicoplanin can be administered orally, and the oral recommended dose is 100-200 mg twice a day for 7 to 14 days. However, in cases of systemic infections, Teicoplanin should not be administered orally.

    Teicoplanin can be administered twice a day intravenously (12 hourly) for three doses, after which it can be administered once daily. It can also be administered orally, and the recommended dose is 100-200 mg orally twice a day for 7 to 14 days. Teicoplanin is available in various forms such as capsules, tablets, syrups, gel, ointment, solutions, and liquids. The mode of administration will depend on the type of infection.

    Duration of the treatment depends on severity and type of infection, and clinical response. A single loading dose of 16 mg/kg body weight is to be used. The half-life of Teicoplanin is 70 to 100 hours, and 97% percent of the drug is excreted through kidneys. Based on the infection, the treatment time varies between 2-4 weeks. You should not exceed Teicoplanin usage for more than 4-months. Consult your physician for additional information.

    There is a possibility that Teicoplanin may cause drug-induced fever. It is seen in cases where drug clearance is lowered due to kidney dysfunction. Since 97% of Teicoplanin is cleared in an unaltered form via kidneys, plasma concentration increases in dysfunction cases and causes fever. It is advisable to consult your doctor if you have a history of renal diseases.

    Yes, Teicoplanin is a semisynthetic antibiotic that belongs to the Glycopeptide antibiotics class used to treat infections caused by gram-positive bacteria. The mechanism of action of Teicoplanin is through inhibition of the formation of the outer covering of bacteria, which is critical for their survival; this hindrance of the outer cover kills the bacteria.
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